منابع مشابه
Nonviral gene transfer to the liver.
2. Bismuth H, Chiche L, Adam R, Castaing G. Liver resection versus transvant issue. First-generation recombinant adenoviruses have plantation for hepatocellular carcinoma in cirrhotic patients. Ann Surg associated toxicity, particularly immunogenicity resulting in 1993;218:145-151. inflammation of transduced tissues in vivo. Recent improve3. Iwatsuki S, Starzl T, Sheahan D, Yokoyama I, Demetris...
متن کاملOcular gene therapy: a review of nonviral strategies.
Along with viral vectors, non-viral strategies have been developed in order to efficiently deliver nucleic acids to ocular cells. During the last decade, we have observed that the outcome of these non-viral delivery systems depends on the genetic material used, the targeted tissue or cells, the expected effect duration, and the routes of administration. Assessment of efficiency has been evaluat...
متن کاملEfficacy of nonviral gene transfer in the canine brain.
OBJECT The purpose of this study was to evaluate the gene transfer capability and tolerability of plasmid DNA/polyethylenimine (PEI) complexes in comparison with adenovirus and naked plasmid DNA in the canine brain. METHODS Plasmid or adenoviral vectors encoding firefly luciferase were injected directly into the cerebral parenchyma of five adult dogs at varying doses and volumes. Serial physi...
متن کاملChallenges in non-viral ocular gene transfer.
Nowadays, there is no effective treatment for many retinal disorders. Knowledge of the genetic basis of many severe ocular diseases may allow for alternative treatments by gene therapy. Non-viral gene complexes, such as lipo- and poly-plexes, can be delivered to the posterior segment, most often the target tissue, by intravitreal or subretinal injection. Since subretinal injections are very inv...
متن کاملAnalysis of novel nonviral gene transfer systems for gene delivery to cells of the musculoskeletal system.
The aim of the present study was to evaluate the efficacy of novel nonviral gene delivery systems in cells of musculoskeletal origin. Primary cultures of lapine skeletal muscle cells, lapine articular chondrocytes, human cells from fibrous dysplasia and cell lines established from human osteosarcoma (SAOS-2), chondrosarcoma (CS-1), murine skeletal myoblasts (L8) and fibroblasts (NIH 3T3) were t...
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ژورنال
عنوان ژورنال: Gene Therapy
سال: 2005
ISSN: 0969-7128,1476-5462
DOI: 10.1038/sj.gt.3302475